The United States

One federal law, fifty-one answers.

Federal law

Federal law applies in every state

Under federal law, psilocybin is illegal everywhere in the United States, including in states that license their own psilocybin programs. It has been a Schedule I controlled substance, the most restrictive federal category, since 1971.

In motion: 6 federal actions recorded in 2026, one executive order and five agency actions. None of them changed the legal status of psilocybin.

States can

  • Write their own criminal laws, and choose not to prosecute
  • License programs, as Oregon and Colorado have

States cannot

  • Shield anyone from federal law
  • Approve psilocybin as a prescription medicine

Nearest date: 21 Aug 2026, the deadline to register to attend or ask to speak at the Food and Drug Administration hearing on the possible future medical use of psychedelic drugs. Registration closes 11:59 pm Eastern. The hearing is on 14 Sep 2026.

As of the reviewThe federal record →
51 jurisdictions · 18 with pending legislation · 128trials in the recruiting stage · reviewed 19 Aug 2026

What changed this year?

This year across the states, newest first. A correction means our reading changed, not the law.

  • OregonRegulatory action

    Oregon has opened a public comment period on new psilocybin rules that would change all licence fees and end reduced fees. Comments run from 1 to 21 September 2026, with public hearings on 15 and 16 September. The state gives rising costs and programme sustainability as the reason.

  • ColoradoRegulatory action

    Colorado's Natural Medicine Division put an emergency fee schedule for the regulated program into effect on 12 Aug 2026, with permanent rulemaking announced for later this year. The legal status of psilocybin in Colorado is unchanged.

  • OregonRegulatory action

    Oregon is taking public comment on a petition to change the rule that sets how facilitator training courses are approved. Comments close 29 Aug 2026. The program itself is unchanged.

  • OregonRegulatory action

    Oregon's psilocybin program laid out its 2026 rule changes: proposed rules publish 1 Sep 2026 and restructure all fees, including ending reduced fees. Public comment runs 1 to 21 Sep, with hearings 15 and 16 Sep. The program's legal status is unchanged.

  • LouisianaChange in law

    Louisiana's psychedelic-assisted therapy initiative became law as Act 956. It takes effect August 1, 2026.

  • Alaskanow recorded as IllegalCorrection

  • ConnecticutChange in law

    Connecticut widened its psilocybin pilot: a law signed on 4 June 2026 opened it beyond veterans and first responders to adults generally. A separate 2025 bill to decriminalize possession passed the House and died in the Senate.

  • Georgianow recorded as IllegalCorrection

Every change, newest first →

Every state, one line each

All fifty states and DC: the current standing, the date it last changed, and whether anything is pending. Open a state for the statute, the sources, and the history.

Legal 2 · Medical use 1 · Decriminalized 5 · Mixed 6 · Illegal 37 · a dot marks pending legislation

Could you join a trial here?

Where US psilocybin trials stand, state by state. Start from your condition to see what is enrolling.

JurisdictionRecruitingActiveCompletedClosedTotal
All US jurisdictions128799616319
Maryland18819348
California171012140
New York1538026
Texas944017
Alabama51118
Georgia436013

And 25 more jurisdictions hold trials.

Statuses as reported by each study team; a multi-site trial counts in each hostAug 2026 review

Closed covers trials terminated, suspended, withdrawn or left unverified. Every row’s four figures add to its own total; a trial with sites in several jurisdictions counts in each, so the place totals do not add to the register’s.

All 323 trials worldwide →

Track changes to psilocybin law.

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