1. What the law is
Arkansas schedules psilocybin and psilocyn at items 28 and 29. The legislature has passed no reform through 2026.
Arkansas adopted the Uniform Controlled Substances Act, and psilocybin and psilocyn sit in its Schedule I at Ark. Code Ann. Section 5-64-204, listed among the hallucinogenic substances. Possession, manufacture and delivery are prosecuted under the Act's penalty provisions at Ark. Code Ann. Sections 5-64-419 et seq. Nothing enacted by 2026 decriminalizes the substance, medicalizes it or authorizes it in any other form.
Arkansas adopted the Uniform Controlled Substances Act, codified at Ark. Code Ann. §§ 5-64-101 et seq., which places hallucinogenic substances, expressly including psilocybin and psilocyn, in Schedule I (Ark. Code Ann. § 5-64-204). Schedule I designation reflects the statutory criteria set out in Ark. Code Ann. § 5-64-203. The Arkansas Department of Health maintains the implementing List of Controlled Substances regulation (007.07.18 Ark. Code R. § 002), which itemizes psilocybin and psilocyn under Schedule I. No reform legislation (decriminalization, a medical or supervised-use framework, or a study task force) has been enacted in Arkansas as of 2026, and no such bill has advanced to law. The substance therefore remains fully prohibited under state law, and no current statute or regulation creates any lawful access pathway.
2. Trials in Arkansas
Interventional psilocybin trials with at least one site in Arkansas, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT06793397 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Site at Pillar Clinical Research - Little Rock | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Start date |
| NCT06308653 | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Sites in Fayetteville and Little Rock | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
Psilocybin remains a Schedule I controlled substance in Arkansas under Ark. Code Ann. § 5-64-204; no reform legislation has been enacted.
4. Proposed laws
No proposed law is on file in Arkansas that would change this entry, as of the 18 Aug 2026 review.
5. Common questions
Is psilocybin legal in Arkansas?
No. Psilocybin (and psilocyn) is a Schedule I controlled substance in Arkansas under the Uniform Controlled Substances Act (Ark. Code Ann. § 5-64-204). It is illegal to possess, manufacture, or deliver.
What statute makes psilocybin illegal in Arkansas?
Ark. Code Ann. § 5-64-204 places psilocybin and psilocyn in Schedule I as hallucinogenic substances. The Arkansas Department of Health's List of Controlled Substances regulation (007.07.18 Ark. Code R. § 002) lists both substances under Schedule I.
Has Arkansas decriminalized or legalized psilocybin?
No. As of 2026, Arkansas has not enacted any law decriminalizing psilocybin, creating a medical or supervised-use program, or establishing a study task force. The substance remains fully prohibited under state law.
Is there a medical psilocybin program in Arkansas?
No. Arkansas has no statute or regulation authorizing medical, therapeutic, or supervised use of psilocybin. It remains a Schedule I controlled substance under Ark. Code Ann. § 5-64-204, with no lawful access pathway.
Are magic mushrooms ("shrooms") legal in Arkansas?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Arkansas.
Read the law
Ark. Code Ann. 5-64-203 and 5-64-204 (Schedule I criteria and statutory list); Arkansas Department of Health List of Controlled Substances, Schedule I items 28-29 (Psilocybin, Psilocyn)1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.healthy.arkansas.gov (opens in new tab) · healthy.arkansas.gov
- 2.healthy.arkansas.gov (opens in new tab) · healthy.arkansas.gov
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
Nothing has needed correcting or updating since this record first published.
Psilocybin Media Group. "Arkansas: psilocybin legal status." The Psilocybin Record, accession US-AR-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/arkansas