1. What the law is
Possession is a third-degree felony in Florida, and the law reaches back a step further than the mushroom. Since 1 July 2025, transporting or selling psilocybin spores and mycelium has been a first-degree misdemeanor in its own right, under SB 700, the 2025 Farm Bill, signed May 15, 2025. The 2026 session passed nothing.
Florida moved in the restrictive direction in 2025, against the loosening trend in most state legislatures. SB 700, the wide-ranging 2025 Farm Bill, was signed by Governor Ron DeSantis on May 15, 2025 and took effect on July 1, 2025. It made transporting, importing, selling or giving away spores or mycelium capable of producing mushrooms containing psilocybin or psilocin, at any point in their life cycle, a first-degree misdemeanor carrying up to one year in jail and a $1,000 fine. Spores themselves contain no controlled substance, so the provision closed what had been a gray area. The underlying prohibition is older and heavier. Psilocybin and psilocin are Schedule I under Florida Statutes section 893.03, possession of any amount is a third-degree felony punishable by up to five years' imprisonment and a $5,000 fine, and sale, manufacture and trafficking carry steeper penalties. Reform has gone nowhere. HB 549 of 2021, the Florida Psilocybin Mental Health Care Act, died in a House subcommittee; the 2022 companion bills directing the Department of Health to study psilocybin, MDMA and ketamine therapies died without a hearing; and no reform legislation passed in the 2026 session.
Florida is one of the few states that tightened its psilocybin law during a period when most state-level activity ran toward study commissions, decriminalization, or regulated therapeutic access, with Oregon and Colorado operating licensed programs. Clinics in Florida lawfully offer ketamine, a Schedule III drug that physicians may prescribe off-label, but that framework does not extend to psilocybin, which remains Schedule I under both state and federal law. With the spore ban newly in force, no reform bill passing in the 2026 session, and the executive branch supportive of the restriction, near-term change appears unlikely absent federal rescheduling or a shift in the Legislature.
2. Trials in Florida
Interventional psilocybin trials with at least one site in Florida, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT07570654 | Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder (opens in new tab)Recruiting in Miami and Orlando | Phase Phase 2/3 | Sponsor COMPASS Pathways | Status Recruiting | Start date |
| NCT06793397 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting in Jacksonville, Maitland, Naples | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Start date |
| NCT06605105 | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Sites in Hollywood, Jacksonville, Lady Lake | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Start date |
| NCT06564818 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Sites in Hollywood, Maitland, Miami | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Start date |
| NCT06308653 | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Sites in Jacksonville, Lauderhill, Orlando | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Start date |
| NCT05711940 | Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Lauderhill, Miami, Miami Lakes | Phase Phase 3 | Sponsor COMPASS Pathways | Status Active, not recruiting | Start date |
| NCT05733546 | A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder (opens in new tab)Site at Clinical Neuroscience Solutions Inc, Jacksonville | Phase Phase 2 | Sponsor COMPASS Pathways | Status Active, not recruiting | Start date |
| NCT05624268 | Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD (opens in new tab)Sites in Orlando and Tampa | Phase Phase 3 | Sponsor COMPASS Pathways | Status Completed | Start date |
| NCT05035927 | Evaluation of Psilocybin (TRP-8802) in the Treatment of Binge Eating Disorder (opens in new tab)Site at University of Florida, Gainesville | Phase Phase 2 | Sponsor TRYP Therapeutics | Status Completed | Start date |
| NCT04353921 | PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder (opens in new tab)Site at Innovative Clinical Research, Inc. (formerly Segal Trials), Lauderhill | Phase Not stated | Sponsor Usona Institute | Status Terminated | Start date |
| NCT03866174 | A Study of Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at Segal Trials, Lauderhill | Phase Phase 2 | Sponsor Usona Institute | Status Completed | Start date |
| NCT00979693 | Psilocybin-Assisted Psychotherapy for Anxiety in People With Stage IV Melanoma (opens in new tab)Site at Mount Sinai Comprehensive Cancer Center, Miami Beach | Phase Phase 2 | Sponsor Multidisciplinary Association for Psychedelic Studies | Status Withdrawn | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
Rep. Michael Grieco files HB 549, the Florida Psilocybin Mental Health Care Act, which would have created a state-regulated psilocybin therapy program; the bill dies in the House Professions and Public Health Subcommittee in April 2021.
SB 348 (Sen. Lauren Book) and companion HB 193 (Rep. Grieco), which would have directed the Department of Health to study therapeutic use of psilocybin, MDMA, and ketamine, die in committee without receiving a hearing.
The Legislature passes SB 700, the 2025 Farm Bill, including a provision criminalizing the transport, import, sale, or gifting of spores and mycelium capable of producing psilocybin or psilocin (Senate 27-9 on April 16; House 88-27 on April 29).
Governor Ron DeSantis signs SB 700 into law on May 15, 2025 (Chapter 2025-22, Laws of Florida).
SB 700 takes effect July 1, 2025; transporting, importing, selling, or giving away psilocybin-capable spores or mycelium becomes a first-degree misdemeanor.
Illegal status takes effect.
No psilocybin reform legislation passes in the 2026 legislative session; possession remains a third-degree felony.
4. Proposed laws
No proposed law is on file in Florida that would change this entry, as of the 16 Aug 2026 review.
5. Common questions
Is psilocybin legal in Florida?
Psilocybin is illegal in Florida.
Are magic mushrooms ("shrooms") legal in Florida?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Florida.
Read the law
SB 700 (2025 Farm Bill) - signed May 15, 2025, effective July 1, 2025; makes transport/sale of psilocybin spores or mycelium a first-degree misdemeanor. Psilocybin possession remains a third-degree felony under existing Florida law.1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.flsenate.gov (opens in new tab) · flsenate.gov
- 2.Marijuana Moment.Marijuana Moment (opens in new tab) · marijuanamoment.net
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
2 changes on file, the latest on . Show allHide
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Checked against the enrolled text of the 2025 act. Florida's spore offence and its penalty are as recorded.
Florida had been marked mixed. Nothing in the record pulls the other way: possession is a felony and the state tightened the law again in 2025, so the status is corrected to illegal. No reform moved in 2026.
Psilocybin Media Group. "Florida: psilocybin legal status." The Psilocybin Record, accession US-FL-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/florida