Mississippi
Psilocybin is illegal in Mississippi as of 16 Aug 2026.1
- Corrected and re-checked against 2 cited sources at this review.
1. What the law is
HB 314 / Chapter 424 (2026): Ibogaine Drug Development Clinical Trial Act, signed March 26, 2026, effective July 1, 2026 (ibogaine only, not psilocybin). SB 2056 / Chapter 322 (2026): trigger law auto-scheduling FDA-approved pharmaceutical psilocybin polymorph upon federal scheduling, signed March 13, 2026, effective July 1, 2026.1
If the FDA ever approves a psilocybin medicine, Mississippi has already written what happens next. SB 2056 (Chapter 322, 2026) is a trigger law: pharmaceutical psilocybin is scheduled for medical use in the state only once the FDA approves it and the DEA reschedules it federally. The other 2026 enactment, the Ibogaine Drug Development Clinical Trial Act (HB 314, Chapter 424), funds FDA clinical trials of ibogaine and nothing else. Psilocybin is Schedule I here, with no access program.
Is psilocybin legal in Mississippi? No. Psilocybin is a Schedule I controlled substance under the Mississippi Uniform Controlled Substances Law (Miss. Code Ann. § 41-29-113), and the state operates no medical, therapeutic, or decriminalized-possession program for it. Possession, sale, and cultivation are criminal offenses prosecuted under the state controlled-substances code. Two 2026 enactments touch adjacent ground, but neither legalizes psilocybin or creates any current path to lawful access.
Psilocybin remains illegal in Mississippi today; the 2026 legislative session produced no change to its status. In that session the Legislature enacted the Ibogaine Drug Development Clinical Trial Act (HB 314, Chapter 424), signed March 26, 2026 and effective July 1, 2026, which directs the State Department of Health to fund FDA clinical trials of ibogaine, a different substance, and does not authorize psilocybin use of any kind. The Legislature also enacted SB 2056 (Chapter 322), signed March 13, 2026 and effective July 1, 2026, a trigger law that would schedule an FDA-approved pharmaceutical psilocybin polymorph for medical use only if and when the U.S. Food and Drug Administration approves it and the federal Drug Enforcement Administration reschedules it. Because that federal action has not occurred, SB 2056 confers no present legal access, and psilocybin remains a Schedule I substance under Mississippi law.
2. Pending legislation
None. Every psilocybin or ibogaine measure filed in the 2026 Regular Session has reached a terminal action: HB 314 and SB 2056 were approved by the Governor as Chapters 424 and 322, HB 563 died on the Senate calendar on 03/11, and SB 2561 and SB 2562 died in committee on 02/03 (Mississippi Legislature, All Measures index for the 2026 Regular Session, checked 16 Aug 2026).
3. History
The laws behind today’s status, when each took effect, and every review since, in order.
Governor signed SB 2056 (Chapter 322), a trigger law that would schedule FDA-approved pharmaceutical psilocybin for medical use only upon future federal rescheduling; effective July 1, 2026.
Governor signed HB 314 (Chapter 424), the Ibogaine Drug Development Clinical Trial Act, funding FDA trials of ibogaine only; effective July 1, 2026. It creates no psilocybin program.
Mississippi's two 2026 laws leave psilocybin where it was: one funds ibogaine trials, the other takes effect only if the federal government moves first. The status is corrected from mixed to illegal.
Both HB 314 and SB 2056 took effect; psilocybin's Schedule I status under Mississippi law was unchanged.
Mississippi's entry no longer lists the state's 2026 ibogaine research law as pending. It was signed in March 2026 and takes effect on 1 July 2026, and no psilocybin measure is pending.
4. Common questions
Is psilocybin legal in Mississippi?
No. Psilocybin is classified as a Schedule I controlled substance under the Mississippi Uniform Controlled Substances Law (Miss. Code Ann. § 41-29-113), and the state has no medical, therapeutic, or decriminalized program permitting its use, possession, or sale.
Did the 2026 Mississippi trigger law (SB 2056) legalize psilocybin?
No. SB 2056 (Chapter 322, 2026) is conditional: it would schedule an FDA-approved pharmaceutical psilocybin polymorph for medical use only if the U.S. Food and Drug Administration approves it and the DEA reschedules it federally. Because that federal action has not occurred, the law provides no current legal access.
Does Mississippi's Ibogaine Drug Development Clinical Trial Act apply to psilocybin?
No. HB 314 (Chapter 424, 2026) funds FDA clinical trials of ibogaine, a separate substance. It establishes no psilocybin trial, pilot, or access program and does not alter psilocybin's Schedule I status.
What are the penalties for psilocybin possession in Mississippi?
Possession is prosecuted under the Mississippi Uniform Controlled Substances Law as a Schedule I controlled substance, with penalties scaling by quantity under Miss. Code Ann. § 41-29-139. Specific charges and sentences depend on the amount and conduct involved; consult the statute and qualified counsel for the current penalty structure.
Are magic mushrooms ("shrooms") legal in Mississippi?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin. Psilocybin is illegal in Mississippi as of 16 Aug 2026. Some laws control the compound and the fungus separately, so this record states the position for psilocybin in Mississippi.
Sources and confidence
Every status line is checked against the primary sources below. How each record is graded for confidence is set out in the methodology.
- 1.billstatus.ls.state.ms.us (opens in new tab) · billstatus.ls.state.ms.us
- 2.mississippitoday.org (opens in new tab) · mississippitoday.org
Cited at the review
This information is for educational purposes only and does not constitute legal advice. Laws change frequently, and enforcement practice can differ from the letter of the law. Verify current status with local authorities before relying on this record.
Changes to this record
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Mississippi's entry no longer lists the state's 2026 ibogaine research law as pending. It was signed in March 2026 and takes effect on 1 July 2026, and no psilocybin measure is pending.
Mississippi's two 2026 laws leave psilocybin where it was: one funds ibogaine trials, the other takes effect only if the federal government moves first. The status is corrected from mixed to illegal.
Mississippi: psilocybin legal status. The Psilocybin Record. Accession US-MS-001. Status as of 16 Aug 2026. https://psilocybinlegalization.com/record/mississippi
If this record changes, know first.
One email when Mississippi's status changes.
No spam. Never shared. Unsubscribe anytime. Privacy statement