1. What the law is
Texas put $50 million into psychedelic research and none of it into access. SB 2308 (2025) created an ibogaine clinical-trial program; when no drug company came forward to partner on it, the state announced in March 2026 that it would run the trials itself through UTHealth Houston and UT Medical Branch Galveston. That money buys trials, not treatment. Possession is still a criminal offense, and no bill legalizes or decriminalizes psilocybin.
Texas maintains full prohibition of psilocybin as a Schedule I controlled substance under the Texas Controlled Substances Act. Possession is a felony. However, the Texas legislature has shown unexpected interest in psilocybin research. In 2021, HB 1802 passed with bipartisan support, directing the state to study the therapeutic potential of psilocybin for veterans with PTSD and treatment-resistant depression. The study, conducted through Baylor College of Medicine and other institutions, is ongoing. Additional bills expanding research access and proposing limited medical exemptions have been introduced in subsequent legislative sessions but have not passed. Texas represents a jurisdiction where the medical research pathway may precede any decriminalization or access legislation.
The veterans' mental health angle has given psilocybin research bipartisan traction in Texas that is rare for drug policy reform in conservative states. HB 1802 passed with support from both Republican and Democratic legislators. This research-first approach could create a pathway to medical access without broader decriminalization, a model other conservative states may follow.
2. Trials in Texas
Interventional psilocybin trials with at least one site in Texas, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT06793397 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting in DeSoto, Houston, San Antonio | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Start date |
| NCT06706232 | Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality (opens in new tab)Recruiting at The University of Texas Health Science Center at Houston, Houston | Phase Phase 2 | Sponsor The University of Texas Health Science Center, Houston | Status Recruiting | Start date |
| NCT06801041 | TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors (opens in new tab)Recruiting at The University of Texas M. D. Anderson Cancer Center, Houston | Phase Phase 2 | Sponsor M.D. Anderson Cancer Center | Status Recruiting | Start date |
| NCT06888128 | State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma (opens in new tab)Recruiting at Baylor College of Medicine, Houston | Phase Phase 2 | Sponsor Baylor College of Medicine | Status Recruiting | Start date |
| NCT06132178 | Psilocybin rTMS for Treatment Resistant Depression (opens in new tab)Recruiting at Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin | Phase Phase 2 | Sponsor University of Texas at Austin | Status Recruiting | Start date |
| NCT06200155 | Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy (opens in new tab)Recruiting at MD Anderson Cancer Center, Houston | Phase Phase 2 | Sponsor M.D. Anderson Cancer Center | Status Recruiting | Start date |
| NCT07227909 | NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy (opens in new tab)Site at MD Anderson Cancer Center, Houston | Phase Phase 2 | Sponsor M.D. Anderson Cancer Center | Status Not yet recruiting | Start date |
| NCT07079852 | The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function (opens in new tab)Site at The University of Texas at Austin Dell Medical School, Austin | Phase Phase 1/2 | Sponsor Manoj Doss | Status Not yet recruiting | Start date |
| NCT06605105 | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Sites in DeSoto and Houston | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Start date |
| NCT06564818 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Sites in DeSoto and Houston | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Start date |
| NCT06308653 | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Sites in Plano and San Antonio | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Start date |
| NCT05711940 | Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Austin, Bellaire, Dallas | Phase Phase 3 | Sponsor COMPASS Pathways | Status Active, not recruiting | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
5 more trials on file for Texas.
The register lists all 17 and filters them by condition, status and phase.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
HB 1802 signed into law, directing study of psilocybin for PTSD and treatment-resistant depression in veterans.
Baylor College of Medicine psilocybin research initiated under HB 1802 mandate, running through 2023.
Additional bills introduced to expand research scope and propose limited medical access.
Research findings expected; may inform future legislative action.
4. Proposed laws
No proposed law is on file in Texas that would change this entry, as of the 16 Aug 2026 review.
5. Common questions
Is psilocybin legal in Texas?
Psilocybin is illegal in Texas.
Are magic mushrooms ("shrooms") legal in Texas?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Texas.
Read the law
SB 2308 (89R, 2025) - ibogaine clinical-trial consortium with $50M state funding, signed and effective June 11, 2025. HB 1802 (2021) psilocybin study expired Sept 2025. Psilocybin remains a Penalty Group 2 controlled substance under Texas law.1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.capitol.texas.gov (opens in new tab) · capitol.texas.gov
- 2.texastribune.org (opens in new tab) · texastribune.org
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
2 changes on file, the latest on . Show allHide
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Texas's entry no longer carries an effective date. Texas has no psilocybin access law, so there is no date to give; the prohibition and the ibogaine research programme are unchanged.
Texas had been recorded as mixed because the state funds psychedelic research. Funding is not access, so the status moved to illegal. SB 2308's effective date was corrected to 11 June 2025, and the state announced in March 2026 that it would run the ibogaine trials itself.
Psilocybin Media Group. "Texas: psilocybin legal status." The Psilocybin Record, accession US-TX-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/texas