1. What the law is
Even a study bill has stalled in Illinois. SB 2772 would create a Psilocybin Advisory Board to make recommendations on psilocybin services, and nothing more; it passed the Senate in May 2026 and has sat in the House Rules Committee since. The bill that would actually license service centers, the Illinois CURE Act (HB 1143), has never had a floor vote. Psilocybin is Schedule I in the state and no psilocybin legislation has been enacted.
Possession of any amount is a felony in Illinois, generally charged as a Class 4 felony, with heavier felony classes for larger quantities and for manufacture or delivery. Psilocybin and psilocin are Schedule I under the Illinois Controlled Substances Act and nothing enacted has changed that. Two bills are alive in the 104th General Assembly and they are very different in ambition. SB 2772, from Senator Rachel Ventura, would create a Psilocybin Advisory Board under the Department of Financial and Professional Regulation to study psilocybin services and recommend training, ethical and licensing standards. It passed the Senate in May 2026 and was re-referred to the House Rules Committee on May 15, 2026, where it sits. HB 1143, the Illinois CURE Act, from Representative La Shawn K. Ford, would take psilocybin and psilocin out of Schedule I altogether and license service centers, facilitators, manufacturers and testing laboratories. It has been in committee since January 2025 with no floor vote. Neither has become law.
Illinois is one of the larger states where psilocybin policy has advanced beyond introduction: the advisory-board measure cleared a full chamber in 2026. The CURE Act is among the most ambitious service-center frameworks introduced in any state, pairing removal from Schedule I with licensing, taxation, and expungement provisions broadly similar to Oregon's regulated-access model. Enactment would create state-licensed psilocybin services in Illinois. The near-term outlook favors the incremental path: the advisory board could advance in a future session, while the full framework faces a longer committee road.
2. Trials in Illinois
Interventional psilocybin trials with at least one site in Illinois, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT06793397 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting at Rush University, Chicago | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Start date |
| NCT06605105 | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Start date |
| NCT06564818 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Start date |
| NCT06308653 | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at Great Lakes Clinical Trials, Chicago | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Start date |
| NCT05399498 | Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder (opens in new tab)Site at University of Chicago, Chicago | Phase Phase 2 | Sponsor University of Chicago | Status Completed | Start date |
| NCT05711940 | Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor COMPASS Pathways | Status Active, not recruiting | Start date |
| NCT05624268 | Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD (opens in new tab)Site at Uptown Research Institute, LLC, Chicago | Phase Phase 3 | Sponsor COMPASS Pathways | Status Completed | Start date |
| NCT03866174 | A Study of Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at Great Lakes Clinical Trials, Chicago | Phase Phase 2 | Sponsor Usona Institute | Status Completed | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
Representative La Shawn K. Ford prefiles House Bill 1, the Illinois CURE Act, for the 103rd General Assembly, the first regulated psilocybin services framework introduced in Illinois.
Senator Rachel Ventura files SB 3695, a Senate version of the CURE Act with bipartisan co-sponsorship; it is assigned to the Senate Executive Committee but does not advance before the session ends.
Representative Ford reintroduces the CURE Act as HB 1143 in the 104th General Assembly; the bill is referred to committee, where it remains without floor action.
SB 2772, Senator Ventura's narrower bill creating a Psilocybin Advisory Board under the Department of Financial and Professional Regulation, passes the Senate.
SB 2772 is re-referred to the House Rules Committee on May 15, 2026, where it stalls; HB 1143 remains in committee without a floor vote.
4. Proposed laws
Proposals that are not yet law and would change this entry if adopted.
SB 2772 (2026): Psilocybin Advisory Board; passed Senate May 2026, re-referred to House Rules Committee May 15, 2026. HB 1143: Illinois CURE Act (regulated psilocybin services framework); in committee since January 2025 without floor action.
5. Common questions
Is psilocybin legal in Illinois?
Psilocybin is illegal in Illinois.
Are magic mushrooms ("shrooms") legal in Illinois?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Illinois.
Read the law
720 ILCS 570/204(d)(16) and (17), Illinois Controlled Substances Act (Schedule I: Psilocybin, Psilocyn)1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.ilga.gov (opens in new tab) · ilga.gov
- 2.illinoissenatedemocrats.com (opens in new tab) · illinoissenatedemocrats.com
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
4 changes on file, the latest on . Show allHide
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Illinois was re-checked on 28 September 2026. Its psilocybin advisory board bill is still parked in the House, the licensing bill has never reached a floor vote, and the entry now cites the statute that keeps psilocybin in Schedule I.
Illinois's verification marker now reflects the July 2026 re-review, which confirmed the record against the legislature's own status pages.
Illinois still lists psilocybin as a Schedule I controlled substance. A Senate-passed advisory board bill remains stalled in the House.
Illinois had been recorded as mixed. Its only psilocybin activity is an advisory board bill and a stalled CURE Act, neither enacted, so the status moved to illegal.
Psilocybin Media Group. "Illinois: psilocybin legal status." The Psilocybin Record, accession US-IL-001, version of 28 Sep 2026. https://psilocybinlegalization.com/record/illinois