Illinois
Psilocybin is illegal in Illinois as of 01 Aug 2026.1
- Checked against 2 cited sources at this review.
1. What the law is
Even a study bill has stalled in Illinois. SB 2772 would create a Psilocybin Advisory Board to make recommendations on psilocybin services, and nothing more; it passed the Senate in May 2026 and has sat in the House Rules Committee since. The bill that would actually license service centers, the Illinois CURE Act (HB 1143), has never had a floor vote. Psilocybin is Schedule I in the state and no psilocybin legislation has been enacted.
Possession of any amount is a felony in Illinois, generally charged as a Class 4 felony, with heavier felony classes for larger quantities and for manufacture or delivery. Psilocybin and psilocin are Schedule I under the Illinois Controlled Substances Act and nothing enacted has changed that. Two bills are alive in the 104th General Assembly and they are very different in ambition. SB 2772, from Senator Rachel Ventura, would create a Psilocybin Advisory Board under the Department of Financial and Professional Regulation to study psilocybin services and recommend training, ethical and licensing standards. It passed the Senate in May 2026 and was re-referred to the House Rules Committee on May 15, 2026, where it sits. HB 1143, the Illinois CURE Act, from Representative La Shawn K. Ford, would take psilocybin and psilocin out of Schedule I altogether and license service centers, facilitators, manufacturers and testing laboratories. It has been in committee since January 2025 with no floor vote. Neither has become law.
Illinois is one of the larger states where psilocybin policy has advanced beyond introduction: the advisory-board measure cleared a full chamber in 2026. The CURE Act is among the most ambitious service-center frameworks introduced in any state, pairing removal from Schedule I with licensing, taxation, and expungement provisions broadly similar to Oregon's regulated-access model. Enactment would create state-licensed psilocybin services in Illinois. The near-term outlook favors the incremental path: the advisory board could advance in a future session, while the full framework faces a longer committee road.
2. Pending legislation
Introduced but not yet law. If a bill passes, this record changes with it.
SB 2772 (2026): Psilocybin Advisory Board; passed Senate May 2026, re-referred to House Rules Committee May 15, 2026. HB 1143: Illinois CURE Act (regulated psilocybin services framework); in committee since January 2025 without floor action.
3. History
The laws behind today’s status, when each took effect, and every review since, in order.
Representative La Shawn K. Ford prefiles House Bill 1, the Illinois CURE Act, for the 103rd General Assembly, the first regulated psilocybin services framework introduced in Illinois.
Senator Rachel Ventura files SB 3695, a Senate version of the CURE Act with bipartisan co-sponsorship; it is assigned to the Senate Executive Committee but does not advance before the session ends.
Representative Ford reintroduces the CURE Act as HB 1143 in the 104th General Assembly; the bill is referred to committee, where it remains without floor action.
SB 2772, Senator Ventura's narrower bill creating a Psilocybin Advisory Board under the Department of Financial and Professional Regulation, passes the Senate.
SB 2772 is re-referred to the House Rules Committee on May 15, 2026, where it stalls; HB 1143 remains in committee without a floor vote.
Illinois had been recorded as mixed. Its only psilocybin activity is an advisory board bill and a stalled CURE Act, neither enacted, so the status moved to illegal.
Illinois still lists psilocybin as a Schedule I controlled substance. A Senate-passed advisory board bill remains stalled in the House.
Illinois's verification marker now reflects the July 2026 re-review, which confirmed the record against the legislature's own status pages.
4. Trials in Illinois
Interventional psilocybin trials with at least one study site in Illinois, drawn from ClinicalTrials.gov, EU CTIS, and ISRCTN. Registry data is reported by sponsors and shown as filed.
Recruiting, active, completed and closed add up to the 8 trials with a study site in Illinois, as of Aug 2026. Closed covers trials terminated, suspended, withdrawn or left unverified.
| Registry ID | Trial | Phase | Sponsor | Status | Started |
|---|---|---|---|---|---|
| NCT06793397 (opens in new tab) | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting at Rush University, Chicago | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Started |
| NCT06605105 (opens in new tab) | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Started |
| NCT06564818 (opens in new tab) | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Started |
| NCT06308653 (opens in new tab) | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at Great Lakes Clinical Trials, Chicago | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Started |
| NCT05399498 (opens in new tab) | Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder (opens in new tab)Site at University of Chicago, Chicago | Phase Phase 2 | Sponsor University of Chicago | Status Completed | Started |
| NCT05711940 (opens in new tab) | Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Chicago and Skokie | Phase Phase 3 | Sponsor COMPASS Pathways | Status Active, not recruiting | Started |
| NCT05624268 (opens in new tab) | Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD (opens in new tab)Site at Uptown Research Institute, LLC, Chicago | Phase Phase 3 | Sponsor COMPASS Pathways | Status Completed | Started |
| NCT03866174 (opens in new tab) | A Study of Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at Great Lakes Clinical Trials, Chicago | Phase Phase 2 | Sponsor Usona Institute | Status Completed | Started |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
5. Common questions
Is psilocybin legal in Illinois?
Psilocybin is illegal in Illinois as of 01 Aug 2026.
Are magic mushrooms ("shrooms") legal in Illinois?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin. Psilocybin is illegal in Illinois as of 01 Aug 2026. Some laws control the compound and the fungus separately, so this record states the position for psilocybin in Illinois.
Sources and confidence
Every status line is checked against the primary sources below. How each record is graded for confidence is set out in the methodology.
- 1.ilga.gov (opens in new tab) · ilga.gov
- 2.illinoissenatedemocrats.com (opens in new tab) · illinoissenatedemocrats.com
Cited at the review
This information is for educational purposes only and does not constitute legal advice. Laws change frequently, and enforcement practice can differ from the letter of the law. Verify current status with local authorities before relying on this record.
Changes to this record
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Illinois's verification marker now reflects the July 2026 re-review, which confirmed the record against the legislature's own status pages.
Illinois still lists psilocybin as a Schedule I controlled substance. A Senate-passed advisory board bill remains stalled in the House.
Illinois had been recorded as mixed. Its only psilocybin activity is an advisory board bill and a stalled CURE Act, neither enacted, so the status moved to illegal.
Illinois: psilocybin legal status. The Psilocybin Record. Accession US-IL-001. Status as of 01 Aug 2026. https://psilocybinlegalization.com/record/illinois
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