United Kingdom

Illegal

Psilocybin is illegal in the United Kingdom as of 16 Aug 2026.1

1. What the law is

Key legislation

Misuse of Drugs Act 1971: psilocin and 'fungus (of any kind) which contains psilocin or an ester of psilocin' are Class A; Schedule 1 under the Misuse of Drugs Regulations 2001. Drugs Act 2005 banned fresh mushrooms.1

The Misuse of Drugs Act 1971 controls psilocin and any fungus of any kind that contains it. Spores hold none, so they are lawful to own and unlawful to germinate. Class A, Schedule 1. The Home Office eased research licensing requirements in 2025.

Sub-national records

2. Pending legislation

July 2025 government response to ACMD barriers-to-research advice: trialling removal of the domestic controlled-drug licence requirement for Schedule 1 research at universities and hospitals with HRA/MHRA approval. The Minister of State's commissioning letter of 2 June 2025 asks the ACMD to draw lessons from the rescheduling of cannabis-based products for medicinal use that would help government assess representations for the potential use of psilocybin and other controlled drugs to treat depression. That advice has not been delivered: the ACMD Chair's work-programme letter of 11 March 2026, which lists every current commissioned and self-commissioned workstream, carries no psilocybin item, and the cannabis-based-medicines review it does list is marked in progress with completion expected in summer 2026. No rescheduling has been enacted, on the legislation.gov.uk change registers for both instruments as checked on 16 August 2026.

3. History

The laws behind today’s status, when each took effect, and every review since, in order.

  1. The United Kingdom's status held at Class A and Schedule 1. The entry now cites GOV.UK directly, and records two things in motion: the July 2025 trial of lighter research licensing, and the psilocybin review the government asked its drugs advisory council to carry out.

    The United Kingdom entry was checked again against the Act, the regulations and the ACMD's own 2026 work programme. Psilocybin remains Class A and Schedule 1, and the review the government commissioned in 2025 has not reported.

4. Trials in the United Kingdom

Interventional psilocybin trials with at least one study site in the United Kingdom, drawn from ClinicalTrials.gov, EU CTIS, and ISRCTN. Registry data is reported by sponsors and shown as filed.

6Recruiting
5Active
10Completed
4Closed
25Total

Recruiting, active, completed and closed add up to the 25 trials with a study site in the United Kingdom, as of Aug 2026. Closed covers trials terminated, suspended, withdrawn or left unverified.

From ClinicalTrials.gov, EU CTIS, and ISRCTN, as of Aug 2026. Showing 12 of 25 trials with a study site in the United Kingdom, recruiting trials first. This site makes no medical claims about psilocybin.
ISRCTN10648713 (opens in new tab)Sleep Blinding Psilocybin, a feasibility study: Examining if participants can tell if they received psilocybin or a placebo when medication is given to act in sleep (opens in new tab)Phase Not statedSponsor King's College LondonStatus Not statedStarted
ISRCTN14487299 (opens in new tab)A clinical trial of 5 mg psilocybin plus psychological support vs 25 mg psilocybin plus psychological support in adults with generalised anxiety disorder (opens in new tab)Phase Not statedSponsor Incannex Healthcare LimitedStatus Not statedStarted
NCT06793397 (opens in new tab)A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting in Cambridge, Doncaster, LondonPhase Phase 3Sponsor Cybin IRL LimitedStatus RecruitingStarted
ISRCTN10232579 (opens in new tab)A trial to investigate if psilocybin therapy is effective in improving outcomes for people with opioid use disorder (opens in new tab)Phase Not statedSponsor Imperial College LondonStatus Not statedStarted
NCT06798636 (opens in new tab)PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm (opens in new tab)Recruiting at Imperial College London, LondonPhase Phase Early 1Sponsor Imperial College LondonStatus RecruitingStarted
NCT06815653 (opens in new tab)Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs (opens in new tab)Recruiting at University College London, LondonPhase Phase 1Sponsor University College, LondonStatus RecruitingStarted
NCT07050368 (opens in new tab)A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers (opens in new tab)Site at Hammersmith Medicines Research (HMR), LondonPhase Phase 1Sponsor MycoMedica Life Sciences PBCStatus CompletedStarted
ISRCTN37167117 (opens in new tab)A study in healthy male volunteers to investigate how the test medicine COMP360 [14C]-psilocybin is taken up, broken down and removed from the body (opens in new tab)Phase Not statedSponsor Compass Pathfinder LimitedStatus Not statedStarted
NCT05723276 (opens in new tab)Psilocybin in Functional Neurological Disorder (opens in new tab)Site at South London and Maudsley NHS Foundation Trust, LondonPhase Not applicableSponsor King's College LondonStatus CompletedStarted
NCT05876481 (opens in new tab)Evaluation of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military Veterans (opens in new tab)Site at Combat Stress, LeatherheadPhase Phase 2Sponsor Combat StressStatus Unknown statusStarted
NCT05711940 (opens in new tab)Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Bodmin, Chertsey, ChesterPhase Phase 3Sponsor COMPASS PathwaysStatus Active, not recruitingStarted
NCT05651126 (opens in new tab)Psilocybin in Adults With and Without Autism Spectrum Disorder (opens in new tab)Site at King's College London, LondonPhase Not applicableSponsor King's College LondonStatus CompletedStarted

ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.

More on the register

13 more trials on file for United Kingdom.

The table above lists the first 12, recruiting first. The register opens on all 25 and narrows further by condition, status, and stage.

See all 25 United Kingdom trials in the register

Condition Treatment Resistant Depression (4) · Depression - Major Depressive Disorder (2) · Depression (2) · Anorexia Nervosa (2) · Major Depressive Disorder (MDD) (1)
Phase Phase 1 (7) · Phase 2 (8) · Phase 3 (2) Status Completed (10) · Unknown status (3) · Recruiting (3)

Registry records remain public on ClinicalTrials.gov and EU CTIS.

5. Common questions

Are magic mushrooms ("shrooms") legal in the United Kingdom?

"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin. Psilocybin is illegal in the United Kingdom as of 16 Aug 2026. Some laws control the compound and the fungus separately, so this record states the position for psilocybin in the United Kingdom.

Sources and confidence

Every status line is checked against the primary sources below. How each record is graded for confidence is set out in the methodology.

  1. 1.UK Government.UK Government (opens in new tab) · gov.uk
  2. 2.UK Government.UK Government (opens in new tab) · gov.uk

Cited at the review

This information is for educational purposes only and does not constitute legal advice. Laws change frequently, and enforcement practice can differ from the letter of the law. Verify current status with local authorities before relying on this record.

Changes to this record

Every change we have made to this record, dated, corrections included. Nothing changes silently.

  1. Review confirmed

    The United Kingdom entry was checked again against the Act, the regulations and the ACMD's own 2026 work programme. Psilocybin remains Class A and Schedule 1, and the review the government commissioned in 2025 has not reported.

  2. Review confirmed

    The United Kingdom's status held at Class A and Schedule 1. The entry now cites GOV.UK directly, and records two things in motion: the July 2025 trial of lighter research licensing, and the psilocybin review the government asked its drugs advisory council to carry out.

Cite this recordGB-001

United Kingdom: psilocybin legal status. The Psilocybin Record. Accession GB-001. Status as of 16 Aug 2026. https://psilocybinlegalization.com/record/united-kingdom

Record 91 of 100 · Last reviewed GB-001

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