Clinical trials

Governments reported 19.22 kilograms of pure psilocybin made in 2024, excluding mushrooms.

Making it lawfully takes four permissions. Two US states publish who holds them, and Canada’s list goes to those seeking access through its Special Access Program or for scientific research, a 2023 filing says.

Analysis · By Allan Kerr · Checked 22 September 2026

In brief

  • Making psilocybin lawfully takes four separate permissions, and no register lists all four in one place. Where a state publishes its licences the count is simple: 21 organizations hold 28 production-side licences across the two American states that do. Canada’s national list goes, a 2023 filing says, to parties interested in access to psilocybin through its Special Access Program or for scientific research.
  • This piece counts who may make psilocybin; who does supply it to trials is a different list, and if you are here about treatment, start here.
An ink drawing on aged cream paper of a long workbench: a tray of thin-stemmed mushrooms drawn in dark green at the left, and laboratory glassware on stands at the right, a heated flask, a coiled condenser, a sealed vessel and a funnel.
Mushrooms grown under a US state licence are left out of the reported kilograms.Illustration for The Psilocybin Record

Four permissions, and a list you have to ask for

A company in Canada that wants to ship psilocybin to a researcher abroad needs four separate authorisations. Health Canada grants three of them, a Dealer’s Licence, a Drug Establishment Licence and an export permit for each shipment, and the export permit waits on the fourth, an import permit from whichever regulator sits at the other end. That stack comes from the registration statement (opens in new tab) Optimi Health Corp. filed on 13 March 2026, a Form F-1/A.

A prospectus supplement (opens in new tab) filed on 8 December 2023, describing Filament Health Corp., says Health Canada’s list of licensed psilocybin producers “is available upon request to parties interested in access to psilocybin through the SAP or for scientific research”. That is ordinary practice for a controlled drug, and one email from somebody in that audience would turn the list into a count.

The list is not published, though. Health Canada’s own psilocybin page (opens in new tab) prints none and tells practitioners who need a supplier to contact the Special Access Program.

Where a register is published, you can count

Two American states publish their licence registers. Twenty-one organizations hold 28 production-side licences at Approved or listed across the two: in Colorado, 8 product manufacturer and 14 standard cultivation licences (opens in new tab) on the 5 September 2026 read, and in Oregon, 6 manufacturer licences on the 1 September 2026 read. Each state issues them under its supervised-services programme, never for retail sale.

Counting every status gives 31 organizations, because the wider count takes in withdrawn, pending and denied licences and adds a fourth class, micro cultivation, that the twenty-one leaves out. A state cultivation licence and a federal dealer’s licence are different instruments, so the two cannot be added into one count.

What Australia’s regulator says about its own powers

Australia lets a doctor lawfully prescribe psilocybin through a restricted authorised-prescriber pathway, which makes it the obvious place to look for a producer. Its Office of Drug Control answered on a page whose stated last update is 25 July 2023:

Under Commonwealth law, we do not have the power to grant permission to manufacture (synthesise) MDMA, cultivate psilocybine-containing mushrooms, or manufacture (synthesise) psilocybine in Australia.
Office of Drug Control, ‘Regulation of MDMA and Psilocybine’, page-stated last update 25 July 2023

The same page sends the rest of the question to the states and territories and to the Therapeutic Goods Administration, which it says does have power to licence the manufacture of psilocybine as a therapeutic good under a Good Manufacturing Practice licence. That is one agency describing its own authority on that date, and it says nothing about who holds an authorisation in Australia today.

No government makes it, and one statute shows that is a choice

In nothing read for this work does a government manufacture psilocybin itself, and this project writes an absence like that only with a positive control on the same document. The Netherlands’ Opium Act supplies one. At articles 8h and 8i (opens in new tab) it has a minister see that enough medicinal cannabis is grown for medical research and for making medicines, and licence only a party the ministry has contracted with. The same Act has no such article for psilocybine, nor for the psilocybin-containing mushrooms that sit on the very schedule cannabis is on, so one legislature built a state supply route for one substance and not the other.

How much actually gets made

Governments report manufacture to the International Narcotics Control Board (opens in new tab), whose published series has four points: approximately 1 kilogram in 2020, 13 in 2022, 36.10 in 2023 and 19.22 in 2024. No figure is published for 2021, when the Board says only that manufacture changed slightly, and the return does not explain why 2023 ran to nearly twice 2024.

What governments report making, in kilograms

  • 2020approx.1 kg
  • 202213 kg
  • 202336.1 kg
  • 202419.22 kg

Four published points. No figure is published for 2021, so no line joins them. Kilograms of pure substance reported by governments under the 1971 Convention. Excludes every mushroom grown under a US state programme: natural material sits outside the treaty that generates this number. A DEA production quota is a ceiling for one country in one year and is not on this axis.

Kilograms of pure psilocybin reported to the INCB by governments; no figure for 2021.

Of the 2024 total, the United Kingdom reported 9.78 kilograms and the United States 9.16, with Canada, Switzerland and Germany reporting a few grams each. The total counts only pure substance under the 1971 Convention, so it excludes every mushroom grown under an American state programme.

The DEA’s aggregate production quota (opens in new tab) for 2026, 50,000 grams of psilocybin and 80,000 of psilocyn, measures something else. A quota is a ceiling for one country in one year, while an INCB return is an actual, across the world, in a different year, so dividing one by the other produces nothing.

In March 2025 the National Institutes of Health bought GMP psilocybin synthesis from Benuvia Operations, LLC, on a task order (opens in new tab) that obligated US$789,896.88. That company is on no row of our own organization register, so the United States government found a manufacturer we had missed, by buying from one.

Every number above comes from a register, a filing or a government data file, and most are linked where they are cited. The two state licence counts are re-derived from the registers by script, and the manufacture series is the International Narcotics Control Board’s own published table.

What we got wrong: the all-status licence count read 39 where the register holds 40, found by an adversarial read of our own data and corrected at the script on 9 September 2026.

What we cannot check from here: Australia’s Office of Drug Control page did not answer a fetch on 11 September 2026, and neither did any other address on that domain, nor did it answer on 22 September 2026, so the quotation above is carried with the page’s own 2023 date and no claim about its present state.

A neighbouring question

Who actually ships the study drug into those trials is a different list again, and an index built on sponsor names cannot see it. That one has its own piece. Australia’s prescribing scheme is followed in a separate piece.

Corrections. Route pending, gated with publication.