1. What the law is
Nobody filed a psilocybin bill in Tennessee's 114th General Assembly. The psychedelics law the state did pass concerns a different drug: the HOPE Treatment Act, SB 2149 substituted for HB 2075, signed by the Governor on 22 May 2026 and filed as Public Chapter 1119. It adds a new Chapter 16 to Title 53 encouraging Tennessee research institutions to join federally authorized ibogaine clinical trials for opioid use disorder and other conditions. Nothing happens under it until the FDA authorizes a trial.
Psilocybin is illegal in Tennessee. It is classified as a Schedule I controlled substance under Tennessee Code Annotated § 39-17-406, the state's controlled-substances scheduling statute, which lists psilocybin and psilocyn among Schedule I hallucinogenic substances. Simple possession is a Class A misdemeanor under Tenn. Code Ann. § 39-17-418, punishable by up to 11 months and 29 days in jail and a fine of up to $2,500, while manufacture, delivery, or sale is prosecuted as a felony under Tenn. Code Ann. § 39-17-417. Tennessee has no law authorizing medical, therapeutic, or supervised use of psilocybin.
Psilocybin remains a Schedule I substance in Tennessee with no legal pathway for personal, medical, or supervised use as of June 2026. In the 2026 session, the General Assembly passed the HOPE Treatment Act (HB 2075 / SB 2149), enacted as Public Chapter 1119 and signed by Governor Bill Lee on May 22, 2026; that act authorizes Tennessee hospitals and qualified research facilities to participate in FDA-authorized clinical trials involving ibogaine and is itself contingent on federal investigational-new-drug authorization. The HOPE Treatment Act concerns ibogaine, not psilocybin, and does not change psilocybin's Schedule I status or create any legal access to psilocybin. No psilocybin-specific legislation advanced in the 2026 session, and neither decriminalization nor any regulated-access framework for psilocybin exists in Tennessee.
2. Trials in Tennessee
Interventional psilocybin trials with at least one site in Tennessee, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT06605105 | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Site at Clinical Neuroscience Solutions, CNS Healthcare, Memphis | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Start date |
| NCT06564818 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Site at Clinical Neuroscience Solutions, CNS Healthcare, Memphis | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
The Tennessee General Assembly advances the HOPE Treatment Act (HB 2075 / SB 2149), an ibogaine clinical-trial research framework; the bill does not address psilocybin.
Governor Bill Lee signs the HOPE Treatment Act into law as Public Chapter 1119, authorizing participation in FDA-authorized ibogaine clinical trials and leaving psilocybin's Schedule I status unchanged.
Psilocybin remains a Schedule I controlled substance under Tenn. Code Ann. § 39-17-406, with no psilocybin-specific legislation enacted in the 2026 session.
4. Proposed laws
None located. The General Assembly's own advanced bill search returns no bill containing the term psilocybin in the 114th General Assembly, searched 16 Aug 2026. The ibogaine HOPE Treatment Act is enacted rather than pending: Public Chapter 1119, signed 22 May 2026.
5. Common questions
Is psilocybin legal in Tennessee?
No. Psilocybin is illegal in Tennessee, where it is classified as a Schedule I controlled substance under Tennessee Code Annotated § 39-17-406. There is no medical, therapeutic, or decriminalized exception under Tennessee law.
What are the penalties for psilocybin possession in Tennessee?
Simple possession of psilocybin is a Class A misdemeanor under Tenn. Code Ann. § 39-17-418, punishable by up to 11 months and 29 days in jail and a fine of up to $2,500. Manufacture, delivery, or sale is charged as a felony under Tenn. Code Ann. § 39-17-417, with penalties that increase based on quantity.
Did the 2026 HOPE Treatment Act legalize psilocybin in Tennessee?
No. The HOPE Treatment Act (HB 2075 / SB 2149), enacted as Public Chapter 1119 and signed on May 22, 2026, authorizes Tennessee facilities to participate in FDA-authorized clinical trials involving ibogaine. It does not mention or apply to psilocybin and does not change psilocybin's Schedule I status.
Is psilocybin decriminalized anywhere in Tennessee?
No. No Tennessee city or county has decriminalized psilocybin, and the state has not enacted any measure deprioritizing enforcement. Psilocybin remains a Schedule I controlled substance statewide under Tenn. Code Ann. § 39-17-406.
Are magic mushrooms ("shrooms") legal in Tennessee?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Tennessee.
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.wapp.capitol.tn.gov (opens in new tab) · wapp.capitol.tn.gov
- 2.nashvillebanner.com (opens in new tab) · nashvillebanner.com
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
2 changes on file, the latest on . Show allHide
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Tennessee had been recorded as mixed on the basis of a law that names only ibogaine. No psilocybin legislation exists in the state, so the status was corrected to illegal.
Tennessee's entry now records that the ibogaine HOPE Treatment Act was signed on 22 May 2026 and became Public Chapter 1119. It does not concern psilocybin, whose status is unchanged.
Psilocybin Media Group. "Tennessee: psilocybin legal status." The Psilocybin Record, accession US-TN-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/tennessee