1. What the law is
South Carolina names psilocybin and psilocyn in its own Schedule I, at section 44-53-190 of the state code. Nothing has been enacted to change that as of 2026, and we have found no psilocybin bill in the legislature.
Psilocybin is illegal in South Carolina. The state classifies both psilocybin and psilocyn as Schedule I controlled substances under South Carolina Code Section 44-53-190(D), which lists hallucinogenic substances the state deems to have a high potential for abuse and no accepted medical use. Manufacture, distribution, and possession are prohibited and prosecuted under the penalty provisions of Section 44-53-370. As of 2026, no enacted state law authorizes any legal psilocybin program in South Carolina.
South Carolina regulates psilocybin through its Controlled Substances Act, codified at Title 44, Chapter 53 of the South Carolina Code of Laws. Section 44-53-190 enumerates Schedule I substances and expressly lists psilocybin and psilocyn among the controlled hallucinogens. The General Assembly has not enacted any decriminalization measure, therapeutic-use framework, or study task force for psilocybin, and no reform bill has passed either chamber. Because no such measure exists, there is no current legal access to psilocybin in South Carolina; the substance remains illegal under state law, and possession, manufacture, and distribution remain offenses under Section 44-53-370.
2. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
South Carolina enacts its Controlled Substances Act (Title 44, Chapter 53), establishing the Schedule I-V framework.
Psilocybin and psilocyn remain Schedule I controlled substances under S.C. Code Section 44-53-190(D); no reform legislation has been enacted.
3. Proposed laws
No proposed law is on file in South Carolina that would change this entry, as of the 18 Aug 2026 review.
4. Common questions
Is psilocybin legal in South Carolina?
No. Psilocybin is illegal in South Carolina. It is classified as a Schedule I controlled substance under South Carolina Code Section 44-53-190(D), and there is no state law authorizing any legal or therapeutic use as of 2026.
What law makes psilocybin illegal in South Carolina?
South Carolina Code Section 44-53-190, part of the state's Controlled Substances Act (Title 44, Chapter 53), lists psilocybin and psilocyn as Schedule I controlled substances. Offenses are penalized under Section 44-53-370.
Has South Carolina decriminalized psilocybin?
No. South Carolina has not decriminalized psilocybin and has not enacted any measure to deprioritize enforcement. Possession remains a criminal offense under state law.
Is there a psilocybin therapy or research program in South Carolina?
No state-authorized psilocybin therapy program or study task force exists in South Carolina as of 2026. The General Assembly has not enacted legislation creating any supervised-use or research framework for psilocybin.
Are magic mushrooms ("shrooms") legal in South Carolina?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in South Carolina.
Read the law
Psilocybin and psilocyn are listed in Schedule I of the South Carolina Controlled Substances Act, at S.C. Code Ann. section 44-53-190(D)(16) and (17).1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.scstatehouse.gov (opens in new tab) · scstatehouse.gov
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
Nothing has needed correcting or updating since this record first published.
Psilocybin Media Group. "South Carolina: psilocybin legal status." The Psilocybin Record, accession US-SC-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/south-carolina