1. What the law is
No Ohio city has decriminalized psilocybin, and the state has enacted nothing either. Psilocybin is Schedule I here, the research proposals floated so far went nowhere, HB 58 of 2023 among them, and nothing has advanced in the current 136th General Assembly. Worth stating plainly: Ohio's statute and legislature websites refuse connections from our systems, so the last review could not re-check this entry against an Ohio government source.
Is psilocybin legal in Ohio? No. Psilocybin and psilocyn are Schedule I controlled substances in Ohio under Ohio Revised Code Chapter 3719, which incorporates the federal Schedule I hallucinogen listing found at 21 C.F.R. 1308.11(d). Possession, manufacture, and distribution are prohibited statewide, and Ohio has enacted no medical, therapeutic, or decriminalization program that authorizes any form of legal access. Drug offenses involving Schedule I substances are charged under Ohio Revised Code Chapter 2925, with penalty levels keyed to the amount involved.
Ohio classifies controlled substances through Ohio Revised Code Chapter 3719, with the State Board of Pharmacy authorized to maintain schedules consistent with the federal Controlled Substances Act; psilocybin and psilocyn appear in Schedule I as hallucinogens, the same classification used federally at 21 C.F.R. 1308.11. The substance is illegal in Ohio now, and the legislative items raised to date have not changed that. Senate Bill 3 of the 133rd General Assembly (2019-2020), a general drug-sentencing reform measure cited in some state trackers, did not pass and did not address psilocybin access. A psilocybin research-related proposal identified as House Bill 58 (135th General Assembly, 2023) failed to advance, and no psilocybin bill has moved through committee in the current 136th General Assembly. Because Ohio has no enacted access law and no operative ballot measure, none of these proposals creates any current lawful route to obtain or use psilocybin in the state.
2. Trials in Ohio
Interventional psilocybin trials with at least one site in Ohio, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT07104916 | Mindfulness-based Psilocybin Therapy for PTSD (opens in new tab)Recruiting at The Ohio State University Medical Center, Columbus | Phase Phase 2 | Sponsor Anthony P King | Status Recruiting | Start date |
| NCT07216404 | Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer (opens in new tab)Recruiting at Ohio State University Comprehensive Cancer Center, Columbus | Phase Phase 2 | Sponsor Alan Davis | Status Recruiting | Start date |
| NCT06605105 | Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) (opens in new tab)Site at Neurobehavioral Clinical Research, Canton | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Enrolling by invitation | Start date |
| NCT06564818 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Site at Neurobehavioral Clinical Research, North Canton | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Active, not recruiting | Start date |
| NCT05711940 | Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD (opens in new tab)Sites in Cincinnati, Cleveland, Columbus | Phase Phase 3 | Sponsor COMPASS Pathways | Status Active, not recruiting | Start date |
| NCT05624268 | Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD (opens in new tab)Sites in Beachwood and North Canton | Phase Phase 3 | Sponsor COMPASS Pathways | Status Completed | Start date |
| NCT05554094 | Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder (opens in new tab)Site at Ohio State University Department of Psychiatry and Behavioral Health at the Davis Medical Research Center, Columbus | Phase Phase 2 | Sponsor Ohio State University | Status Active, not recruiting | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
Ohio's modern controlled-substances framework under Ohio Revised Code Chapter 3719 places psilocybin and psilocyn in Schedule I, mirroring the federal hallucinogen listing.
Senate Bill 3 of the 133rd General Assembly, a general drug-sentencing reform bill that did not address psilocybin, failed to pass.
A psilocybin research-related proposal identified as House Bill 58 (135th General Assembly) was introduced but did not advance.
As of mid-2026, no psilocybin bill has cleared committee in the 136th General Assembly, and psilocybin remains a Schedule I controlled substance in Ohio.
4. Proposed laws
Proposals that are not yet law and would change this entry if adopted.
Nothing with movement as of the 16 Aug 2026 review. One outside tracker lists a psilocybin-assisted therapy pilot proposal as HB 249 of 2025, which has not advanced; the official HB 249 in the 136th General Assembly appears to address an unrelated subject, so that bill number may be misattributed. No psilocybin bill with committee-level movement was found in the 2025-2026 session.
5. Common questions
Is psilocybin legal in Ohio?
No. Psilocybin and psilocyn are Schedule I controlled substances in Ohio under Ohio Revised Code Chapter 3719, consistent with the federal Schedule I listing at 21 C.F.R. 1308.11(d). There is no enacted medical, therapeutic, or decriminalization program authorizing legal access anywhere in the state.
Has any Ohio city decriminalized psilocybin?
Ohio's state controlled-substances law continues to apply statewide, and no Ohio municipal decriminalization measure has been identified that creates a lawful route to possess or use psilocybin. Any local enforcement-priority resolution would not change the substance's Schedule I status under state law.
What is the penalty for psilocybin possession in Ohio?
Psilocybin is a Schedule I controlled substance, and offenses involving it are charged under Ohio Revised Code Chapter 2925. Penalty levels depend on the offense and the amount involved; specific charges and consequences should be assessed with a licensed Ohio attorney.
Is there a legal psilocybin therapy program in Ohio?
No. Ohio has not enacted a supervised or medical psilocybin program. Proposals raised in prior General Assemblies did not pass, and no psilocybin bill has advanced through committee in the current 136th General Assembly, so no lawful therapeutic access exists in the state.
Are magic mushrooms ("shrooms") legal in Ohio?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Ohio.
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.legislature.ohio.gov (opens in new tab) · legislature.ohio.gov
- 2.Mind Medicine Law.Mind Medicine Law (opens in new tab) · mindmedicinelaw.com
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
3 changes on file, the latest on . Show allHide
Every change we have made to this record, dated, corrections included. Nothing changes silently.
Ohio's entry now dates its no-bills-with-movement claim to the 16 Aug 2026 review. The one cited proposal, listed as HB 249 of 2025, still shows no committee movement.
Ohio's entry was reviewed on 16 August 2026 without being re-checked against an Ohio government source, because Ohio's own statute and legislature websites could not be reached. Nothing was changed.
Nothing enacted, no city measure, and no bill moving in the current General Assembly. Ohio's entry was corrected from mixed to illegal.
Psilocybin Media Group. "Ohio: psilocybin legal status." The Psilocybin Record, accession US-OH-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/ohio