1. What the law is
Alabama lists psilocybin and psilocyn in Schedule I at Ala. Code 20-2-23(b)(3). The state has enacted no change to that as of 2026.
Both psilocybin and psilocyn are named in Alabama's Schedule I, at Alabama Code Section 20-2-23(b)(3)(o)-(p). That is the most restrictive tier the Alabama Uniform Controlled Substances Act provides, and possession, manufacture, sale and distribution are criminal offenses under it. Alabama law carves out no medical, therapeutic or decriminalized use, and the legislature had enacted no such measure as of 2026.
Psilocybin's Schedule I status in Alabama derives from the Alabama Uniform Controlled Substances Act (Title 20, Chapter 2 of the Code of Alabama), which mirrors the federal Controlled Substances Act in placing psilocybin and psilocyn among substances the legislature has classified as having high abuse potential and no accepted state-recognized use. As of 2026, the Alabama Legislature has enacted no bill to decriminalize, reschedule, or create a regulated-access program for psilocybin, and no psilocybin study task force, pilot program, or therapeutic-access framework exists under Alabama law. No trigger law or contingent statute is in effect, so the substance remains fully prohibited; any future change would require new legislation passed by the Alabama Legislature. Searches of the 2024, 2025, and 2026 regular sessions identify no psilocybin reform measure advancing through the legislature.
2. Trials in Alabama
Interventional psilocybin trials with at least one site in Alabama, as their sponsors filed them with ClinicalTrials.gov, EU CTIS and ISRCTN. Each row links to the registry record, which sets out who may take part.
Recruiting or opening counts trials recruiting now, not yet recruiting, or enrolling by invitation. Closed counts trials terminated, suspended, withdrawn or left unverified by their sponsors.
| Registry ID | Trial | Phase | Sponsor | Status | Start date |
|---|---|---|---|---|---|
| NCT07226232 | Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression (opens in new tab)Recruiting in Birmingham and Tuscaloosa | Phase Phase 3 | Sponsor VA Office of Research and Development | Status Recruiting | Start date |
| NCT06793397 | A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder (opens in new tab)Recruiting at UAB Psychiatry and Behavioral Neurology, Birmingham | Phase Phase 3 | Sponsor Cybin IRL Limited | Status Recruiting | Start date |
| NCT05068791 | Psilocybin-facilitated Treatment for Chronic Pain (opens in new tab)Recruiting at UAB Beacon Tower, Birmingham | Phase Phase Early 1 | Sponsor University of Alabama at Birmingham | Status Recruiting | Start date |
| NCT05452772 | 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder (opens in new tab)Recruiting at University of Alabama at Birmingham, Birmingham | Phase Phase 2 | Sponsor Johns Hopkins University | Status Recruiting | Start date |
| NCT07774702 | Psilocybin for Methamphetamine Use Disorder (opens in new tab)Site at University of Alabama at Birmingham, Birmingham | Phase Phase 2 | Sponsor Peter Hendricks | Status Not yet recruiting | Start date |
| NCT06308653 | Psilocybin for Major Depressive Disorder (MDD) (opens in new tab)Site at University of Alabama Clinical Research Unit, Birmingham | Phase Phase 3 | Sponsor Usona Institute | Status Active, not recruiting | Start date |
| NCT05227742 | Exploratory Study of Low Dose Psilocybin (opens in new tab)Site at University of Alabama at Birmingham, Birmingham | Phase Phase Early 1 | Sponsor University of Alabama at Birmingham | Status Withdrawn | Start date |
| NCT02037126 | Psilocybin-facilitated Treatment for Cocaine Use (opens in new tab)Site at UAB Outpatient Clinical Research Unit, Birmingham | Phase Phase 2 | Sponsor University of Alabama at Birmingham | Status Completed | Start date |
ClinicalTrials.gov data courtesy of the U.S. National Library of Medicine.
3. History
The legal events behind this entry, dated and oldest first. Our own reviews and corrections are listed under Changes to this record.
Alabama enacts the Alabama Uniform Controlled Substances Act (Title 20, Chapter 2, Code of Alabama), establishing the state's controlled-substance schedules.
Psilocybin and psilocyn remain Schedule I controlled substances under Alabama Code Section 20-2-23; no psilocybin reform legislation has been enacted.
4. Proposed laws
No proposed law is on file in Alabama that would change this entry, as of the 18 Aug 2026 review.
5. Common questions
Is psilocybin legal in Alabama?
No. Psilocybin is illegal in Alabama. It and its metabolite psilocyn are listed as Schedule I controlled substances under Alabama Code Section 20-2-23, and no state law authorizes medical, therapeutic, or recreational use.
What is the penalty for psilocybin possession in Alabama?
Because psilocybin is a Schedule I controlled substance, possession is prosecuted as unlawful possession of a controlled substance under the Alabama Uniform Controlled Substances Act (Title 20, Chapter 2, Code of Alabama). Manufacture, sale, and distribution are separately charged offenses. Specific charges and sentencing depend on the conduct and quantity; consult the controlling statutes or a licensed attorney for case-specific exposure.
Has Alabama decriminalized psilocybin?
No. Alabama has not decriminalized psilocybin. As of 2026, the Alabama Legislature has enacted no measure to decriminalize, reschedule, or deprioritize enforcement of psilocybin offenses, and the substance remains a Schedule I controlled substance under Alabama Code Section 20-2-23.
Does Alabama have a psilocybin therapy or medical-access program?
No. No Alabama statute authorizes supervised, medical, or therapeutic psilocybin use, and no study task force or pilot program has been established under state law. Any such program would require new legislation enacted by the Alabama Legislature.
Are magic mushrooms ("shrooms") legal in Alabama?
"Magic mushrooms" and "shrooms" are common names for fungi that contain psilocybin, and this entry states the law on psilocybin itself, which some laws treat separately from the fungus. Psilocybin is illegal in Alabama.
Read the law
Ala. Code § 20-2-23(b)(3) (Schedule I: Psilocybin, Psilocyn); Ala. Admin. Code 420-7-2 App. A (official Controlled Substances List)1
Sources
This entry's status is checked against the primary sources below, and the methodology explains how each entry is graded for confidence.
- 1.adfs.alabama.gov (opens in new tab) · adfs.alabama.gov
- 2.codes.findlaw.com (opens in new tab) · codes.findlaw.com
This entry is for information only and is not legal or medical advice. Laws change, and enforcement can differ from the letter of the law, so check the current position against the primary sources above before relying on it.
Changes to this record
Nothing has needed correcting or updating since this record first published.
Psilocybin Media Group. "Alabama: psilocybin legal status." The Psilocybin Record, accession US-AL-001, version of 23 Aug 2026. https://psilocybinlegalization.com/record/alabama